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Currently, the leading cause of death in the U.S. is heart disease. Usually, the precursor leading to cardiovascular (CV) events in patients is hypertension. The current guidelines (JNC VIII) has a standard treatment goal of a systolic blood pressure <140 mmHg in order to prevent future CV complications. The purpose of this study is to compare the current standard treatment of the systolic blood pressure goal of <140 mmHg to a more intensive goal of <120 mmHg. We believe this study could be applied to this practice setting because it can possibly lead to a change in therapeutic blood pressure target goals. The study shows that there was a significant decrease of a 0.54% absolute risk reduction in rate of primary endpoints which included: myocardial infraction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes. It appears that the use of intensive treatment decreases the rate of CV events as compared to standard treatment. The result of this study can definitely have an impact on the development of future hypertension guidelines.
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Link to the full abstract review: NEJM Abstract Review 151111